Keywords:Inflammation, immune response, macrophages, adhesion, mesenchymal stem cells, tissue regeneration, placenta
Research interest:Placenta accreta is defined as a pathologic attachment of the placenta to the uterus. There is little doubt that the worldwide caesarean delivery epidemic has led to an increased incidence of abnormally adherent and invasive placentation, so called morbidly adherent placenta (MAP). To date it is not clear which pathomechanisms are the underlying cause for the pathological placental invasion. Only few reports have been published regarding basic histological and immunological parameters in MAP (1–5). The aim is to find a correlation of histological, immunological and endometrial stem cell properties in MAP.
Collaborations within the DP-iDP:
Collaborating research groups where PhD students could perform their research stay abroad:
Industrial partners:A.M.I. Agency for Medical Innovations GmbH, Feldkirch, Austria
Know-how and infrastructure of the research group:Studies are routinely carried out both in the laboratory and in the clinical setting. The clinical research group comprises four consultants and three diploma students and has a long lasting experience in the design and conduction of prospective clinical studies. The basic science research group consists of one doctoral student and is in collaboration with G. Desoye and C. Wadsack. Various techniques are being used for a detailed analysis of MSC. All the required equipment is available at the institute, including animal and cell culture facilities, flow cytometry, real-time PCR systems, fluorescence plate reader, tissue processing and fluorescence microscopy, and a microscopy system to study cell-to-cell interaction.
Scientific concepts and techniques that students will learn in this laboratory:DP-iDP students will be trained in stem cell culture laboratory skills. Students will learn how to isolate MSC, extract them from the tissue and characterize them using various techniques. The acquired methodologies will comprise flow cytometry, cell differentiation, cell labeling, western blot, and various types of microscopy.