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Ute Panzenboeck, PhD:

Nuclear receptors regulating metabolism and inflammatory mediators in endothelial cells

Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Chair of Pathophysiology and Immunology, Medical University of Graz, Heinrichstraße 31a, A-8010 Graz;
phone: +43-316-380 1955, fax: +43-316-380 9640, ✉ e-mail
• Profile     • Curriculum vitae     • PhD students     • Grants     • Publications ⏬    

List of publications:

10 most significant publications:

  1. Zandl-Lang M, Fanaee-Danesh E, Sun Y, Albrecher NM, Gali CC, Cancar I, Kober A, Tam-Amersdorfer C, Stracke A, Storck SM, Saeed A, Stefulj J, Pietrzik CU, Wilson MR, Björkhem I, Panzenboeck U: Regulatory effects of simvastatin and apoJ on APP processing and amyloid-β clearance in blood-brain barrier endothelial cells. Biochim Biophys Acta, 2018; 1863(1):​40–60.
  2. Kober AC, Manavalan APC, Tam-Amersdorfer C, Holmér A, Saeed A, Fanaee-Danesh E, Zandl M, Albrecher NM, Björkhem I, Kostner GM, Dahlbäck B, Panzenboeck U: Implications of cerebrovascular ATP-binding cassette transporter G1 (ABCG1) and apolipoprotein M in cholesterol transport at the blood-brain barrier. JRNL, Biochimm Biophys Acta, 2017; 1862(6):​573–588.
  3. Chirackal Manavalan AP, Kober A, Metso J, Lang I, Becker T, Hasslitzer K, Zandl M, Fanaee-Danesh E, Pippal JB, Sachdev V, Kratky D, Stefulj J, Jauhiainen M, Panzenboeck U: Phospholipid transfer protein is expressed in cerebrovascular endothelial cells and involved in high density lipoprotein biogenesis and remodeling at the blood-brain barrier. J Biol Chem, 2014; 289(8):​4683–4698.
  4. Scholler M, Wadsack C, Lang I, Etschmaier K, Schweinzer C, Marsche G, Dieber-Rotheneder M, Desoye G, Panzenboeck U: Phospholipid transfer protein in the placental endothelium is affected by gestational diabetes mellitus. J Clin Endocrinol Metab, 2012; 97(2):​437–445.
  5. Etschmaier K, Becker T, Eichmann TO, Schweinzer C, Scholler M, Tam-Amersdorfer C, Poeckl M, Schuligoi R, Kober A, Chirackal Manavalan AP, Rechberger GN, Streith IE, Zechner R, Zimmermann R, Panzenboeck U: Adipose triglyceride lipase affects triacylglycerol metabolism at brain barriers. J Neurochem, 2011; 119(5):​1016–1028.
  6. Schweinzer C, Kober A, Lang I, Etschmaier K, Scholler M, Kresse A, Sattler W, Panzenboeck U: Processing of endogenous AβPP in blood-brain barrier endothelial cells is modulated by liver-X receptor agonists and altered cellular cholesterol homeostasis. J Alzheimers Dis, 2011; 27(2):​341–360.
  7. Stefulj J, Panzenboeck U, Becker T, Hirschmugl B, Schweinzer C, Lang I, Marsche G, Sadjak A, Lang U, Desoye G, Wadsack C: Human endothelial cells of the placental barrier efficiently deliver cholesterol to the fetal circulation via ABCA1 and ABCG1. Circ Res, 2009; 104(5):​600–608.
  8. Panzenboeck U, Andersson U, Hansson M, Sattler W, Meaney S, Björkhem I: On the mechanism of cerebral accumulation of cholestanol in patients with cerebrotendinous xanthomatosis. J Lipid Res, 2007; 48(5):​1167–1174.
  9. Panzenboeck U, Kratzer I, Sovic A, Wintersperger A, Bernhart E, Hammer A, Malle E, Sattler W: Regulatory effects of synthetic liver X receptor- and peroxisome-proliferator activated receptor agonists on sterol transport pathways in polarized cerebrovascular endothelial cells. Int J Biochem Cell Biol, 2006; 38(8):​1314–1329.
  10. Panzenboeck U, Balazs Z, Sovic A, Hrzenjak A, Levak-Frank S, Wintersperger A, Malle E, Sattler W: ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cells. J Biol Chem, 2002; 277(45):​42781–42789.

30.05.2018 DP-iDP Doctoral Programme “Inflammatory Disorders in Pregnancy”