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Ákos Heinemann, MD:

Leukocyte trafficking, activation and inflammatory mediators

Otto Loewi Research Centre, Division of Pharmacology, Medical University of Graz, Universitätsplatz 4, A-8010 Graz;
phone: +43-316-380 4508, fax: +43-316-380 9645, ✉ e-mail
• Profile     • Curriculum vitae     • PhD students     • Grants     • Publications ⏬    

List of publications:

10 most significant publications:

  1. Jandl K, Stacher E, Bálint Z, Sturm EM, Maric J, Peinhaupt M, Luschnig P, Aringer I, Fauland A, Konya V, Dahlen SE, Wheelock CE, Kratky D, Olschewski A, Marsche G, Schuligoi R, Heinemann A: Activated prostaglandin D2 receptors on macrophages enhance neutrophil recruitment into the lung. J Allergy Clin Immunol, 2016; 137(3):833–843.
  2. Konya V, Üllen A, Kampitsch N, Theiler A, Philipose S, Parzmair GP, Marsche G, Peskar BA, Schuligoi R, Sattler W, Heinemann A: Endothelial E-type prostanoid 4 receptors promote barrier function and inhibit neutrophil trafficking. J Allergy Clin Immunol, 2013; 131(2):532–540.e1-2.
  3. Sedej M1, Schröder R, Bell K, Platzer W, Vukoja A, Kostenis E, Heinemann A, Waldhoer M: D-type prostanoid receptor enhances the signaling of chemoattractant receptor-homologous molecule expressed on TH2 cells. J Allergy Clin Immunol, 2012; 129(2):492–500.e1-9.
  4. Konya V, Sturm EM, Schratl P, Beubler E, Marsche G, Schuligoi R, Lippe IT, Peskar BA, Heinemann A: Endothelium-derived prostaglandin I2 controls the migration of eosinophils. J Allergy Clin Immunol, 2010; 125(5):1105–1113.
  5. Blättermann S, Peters L, Ottersbach PA, Bock A, Konya V, Weaver CD, Gonzalez A, Schröder R, Tyagi R, Luschnig P, Gäb J, Hennen S, Ulven T, Pardo L, Mohr K, Gütschow M, Heinemann A, Kostenis E: A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer. Nat Chem Biol, 2012; 8(7):631–638.
  6. Philipose S, Konya V, Sreckovic I, Marsche G, Lippe IT, Peskar BA, Heinemann A, Schuligoi R: The prostaglandin E2 receptor EP4 is expressed by human platelets and potently inhibits platelet aggregation and thrombus formation. Arterioscler Thromb Vasc Biol, 2010; 30(12): 2416–2423.
  7. Böhm E, Sturm GJ, Weiglhofer I, Sandig H, Shichijo M, McNamee A, Pease JE, Kollroser M, Peskar BA, Heinemann A: 11-Dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils. J Biol Chem, 2004; 279: 7663–7670.
  8. Sturm GJ, Böhm E, Trummer M, Weiglhofer I, Heinemann A, Aberer W: The CD63 basophil activation test in Hymenoptera venom allergy: a prospective study. Allergy, 2004; 59: 1110–1117.
  9. Sturm GJ, Schuligoi R, Sturm EM, Royer JF, Lang-Loidolt D, Stammberger H, Amann R, Peskar BA, Heinemann A: 5-Oxo-6,8,11,14-eicosatetraenoic acid is a potent chemoattractant for human basophils. J Allerg Clin Immunol, 2005; 116(5): 1014–1019.
  10. Heinemann A, Sturm GJ, Ofner M, Sturm EM, Weller C, Peskar BA, Hartnell A: Stem cell factor stimulates the chemotaxis, integrin upregulation, and survival of human basophils. J Allerg Clin Immunol, 2005; 116: 820–826.

28.05.2018 DP-iDP Doctoral Programme “Inflammatory Disorders in Pregnancy”